terça-feira, 19 de abril de 2011

Aterosclerose e Estenose Aórtica... Espectros de uma mesma doença?

- Este artigo não trata do velho assunto Estatina x Estenose aórtica, mas sim da presença de hemorragia intravalvular podendo contribuir para rápida progressão da estenose aórtica degenerativa, tal qual ocorre em placas ateroscleróticas em coronárias, aorta e carótidas.

Intraleaflet haemorrhage is associated with rapid progression of degenerative aortic valve stenosis

Hirokuni Akahori1, Takeshi Tsujino2*, Yoshiro Naito1, Mika Matsumoto1, Masaaki Lee-Kawabata1, Mitsumasa Ohyanagi3, Masataka Mitsuno4, Yuji Miyamoto4, Takashi Daimon5, Hiroyuki Hao6, Seiichi Hirota6, and Tohru Masuyama1

Aims - The haemorrhage in the plaque (intraplaque haemorrhage) plays a critical role in the progression of atherosclerosis. The purpose of this study is to clarify whether the haemorrhage in the aortic valve leaflet (intraleaflet haemorrhage) accelerates the progression of aortic valve stenosis (AS).

Methods and results - We examined specimens of aortic valve leaflets obtained from 36 patients who had undergone aortic valve replacement for degenerative AS and in whom echocardiographic data were available just before the operation and at least 180 days before the last study. The stenotic valves were examined by immunohistochemistry to detect intraleaflet haemorrhage with antibody against glycophorin A, an erythrocyte-specific protein. The progression of AS was assessed by annualized change in the aortic valve area (DAVA: cm2/year). The patients were divided into two groups, namely the rapid progression group (DAVA ≥ 0.1 cm2/year) and the slow progression group (DAVA , 0.1 cm2/year), according to the reported average progression rate of AS. Intraleaflet haemorrhage was observed in 78 % of the specimens. Intraleaflet haemorrhage was associated with neovascularization and macrophage infiltration. The areas of intraleaflet haemorrhage and macrophage infiltration were greater in the rapid progression group than in the slow progression group. Multivariate analysis has shown that the area of intraleaflet haemorrhage was the sole independent factor that positively correlated with DAVA.
Conclusions Intraleaflet haemorrhage was frequently observed in the valve leaflets of degenerative AS and associated with a rapid progression of AS.

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